Slaughter, who did not play as a freshman, tore his left Achilles tendon in the third game of the season, a 20-3 victory over Michigan State.
"I understood that a sixth year was far from a guarantee," Slaughter said. "It is sad to know that my time at Notre Dame as a football player is complete, but it doesn't lessen my love for this University and its football program. This decision simply begins the next chapter of my life and I'll be forever grateful for my coaches, teammates and all the Irish fans that supported me throughout my career."
Slaughter started 19 games in four seasons and played in 39, finishing with 98 tackles, two interceptions and two sacks.
“I appreciate the NCAA taking the time to thoroughly look into Jamoris’ application for a sixth year,” Irish head coach Brian Kelly said. “Jamoris is a first-class young man and most importantly leaves Notre Dame with his degree. We wish him all the best as he now pursues his dream of playing in the NFL.”
Slaughter's most productive season came in 2011 when he collected 45 tackles, four tackles for loss, three passes defended, two interceptions, two sacks and a forced fumble.
Slaughter graduated from Notre Dame in 2012. He has been invited to the NFL Combine later this month in Indianapolis,